Capillary Permeability to Plasma Proteins

Capillary Permeability to Plasma Proteins.

ACCORDING to the classical hypothesis of Starling (1896) the exchange of water and small lipid-insoluble molecules across the capillary membrane is largely governed by the balance between hydrostatic and colloid osmotic pressures, the existence of the latter being dependent upon relative impermeability of the capillary membrane to plasma proteins. Starling's concept has been verified by direct ...

Capillary permeability to macromolecules.

PKQuest: capillary permeability limitation and plasma protein binding – application to human inulin, dicloxacillin and ceftriaxone pharmacokinetics

BACKGROUND It is generally assumed that the tissue exchange of antibiotics is flow limited (complete equilibration between the capillary and the tissue water). This assumption may not be valid if there is a large amount of plasma protein binding because the effective capillary permeability depends on the product of the intrinsic capillary permeability (PS) and the fraction of solute that is fre...

Multiple pathways of capillary permeability.

Morphological and physiological studies indicate multiple routes for transport across capillary endothelium. However, the identification of the morphological counterparts of specific transport processes (or the assignment of specific transport roles to morphologically identifiable pathways) has been only partly achieved: the contribution of endothelial cell membranes to transport of water and s...

Intercellular cement and capillary permeability.

The passage of materials across a membrane consisting of cells, e.g., the cap& lary wall, requires a consideration of several structural tors. Environmental effects may be mediated through the exertion of may be purely nt of material passed through in a permeability characteristics of the and environmental f acchemical action on the structure of pressure on the membrane the membrane. or they ma...